Cib1 ELISA Kit for Mouse(Mus musculus) | EIAab.comCib1 ELISA Kit for Mouse(Mus musculus)

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Cib1 (Gene name),

Calcium and integrin-binding protein 1 (Protein name ), CIB1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Cib1(Cib;Kip;Prkdcip);

Protein name:

Calcium and integrin-binding protein 1(CIB);

Alternative:

DNA-PKcs-interacting protein;Calmyrin;Kinase-interacting protein(KIP);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer (By similarity). Interacts with the heterodimeric integrin alpha-IIb/beta3 (By similarity). Interacts with the protein kinases PLK2/SNK and with the region immediately upstream of the kinase domain of DNA-PK (By similarity). Interacts with PSEN2 (By similarity). Interacts (via C-terminus) with F8 (By similarity). Interacts with NBR1 (via C-terminus) (By similarity). Interacts with FEZ1 (via C-terminus) (By similarity). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation (By similarity). Interacts with IFI6 (By similarity). Interacts with BCL2 (By similarity). Interacts with TAS1R2 (via C-terminus); this interaction is independent of the myristoylation state of CIB1 (By similarity). Interacts with ITPR3; in a calcium dependent manner (By similarity). Interacts with PTK2 (By similarity). Interacts with MAP3K5; inhibiting MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2 (By similarity). Interacts with MYO1C.

Function:

May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain (By similarity). Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes) (By similarity). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways (By similarity). May play a role in regulation of apoptosis (By similarity). Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.

Subcellular Location:

Membrane Lipid-anchor Cytoplasm Nucleus Cell projection filopodium Apical cell membrane Localizes to the perinuclear region in the presence of NBR1 (By similarity). Colocalizes with TAS1R2 in apical regions of taste receptor cells.

Protein Attributes:

Sequence length:

191

Sequence:

50:

100:

150:

191:

QLIDNILEES | DIDRDGTINL | SEFQHVISRS | PDFASSFKIV | L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:23991

UniGene:

Mm.30217

Pfam:

PF13499

SMR:

Q9Z0F4

String:

Q9Z0F4

Uniprot:

Q9Z0F4

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ELISA Kit for Mouse CIB

Cat.:

E1394h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse CIB

Cat.:

E1394b

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Packing:

96T

ELISA Kit for Mouse CIB

Cat.:

E1394m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse CIB

Cat.:

E1394r

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Packing:

96T

CLIA Kit for Mouse CIB

Cat.:

U1394r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse CIB

Cat.:

U1394m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse CIB

Cat.:

U1394h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse CIB

Cat.:

U1394b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse CIB

Cat.:

P1394Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse CIB

Cat.:

P1394Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse CIB

Cat.:

P1394Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse CIB

Protein for Mouse CIB

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Structure, expression profile, and chromosomal location of a mouse gene homologous to human DNA-PKcs interacting protein (KIP) gene."
Saito T. , Seki N. , Hattori A. , Hayashi A. , Abe M. , Araki R. , Fujimori A. , Fukumura R. , Kozuma S. , Matsuda Y.
Mamm. Genome10:315-317(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6.
tissue: Fetal kidney.
2.

"Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP)."
Hattori A. , Seki N. , Hayashi A. , Kozuma S. , Saito T.
DNA Seq.10:415-418(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Cloning and tissue distribution of murine calcium and integrin binding protein, CIB."
Naik M.U. , Naik U.P.
Submitted (1999-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Bone marrow.
tissue: Kidney.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Colon.
tissue: Mammary gland.
6.

"CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation."
Yuan W. , Leisner T.M. , McFadden A.W. , Wang Z. , Larson M.K. , Clark S. , Boudignon-Proudhon C. , Lam S.C. , Parise L.V.
J. Cell Biol.172:169-175(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
7.

"CIB1 is essential for mouse spermatogenesis."
Yuan W. , Leisner T.M. , McFadden A.W. , Clark S. , Hiller S. , Maeda N. , O'Brien D.A. , Parise L.V.
Mol. Cell. Biol.26:8507-8514(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
8.

"CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis."
Zayed M.A. , Yuan W. , Leisner T.M. , Chalothorn D. , McFadden A.W. , Schaller M.D. , Hartnett M.E. , Faber J.E. , Parise L.V.
Circ. Res.101:1185-1193(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
9.

"CIB1 and CaBP1 bind to the myo1c regulatory domain."
Tang N. , Lin T. , Yang J. , Foskett J.K. , Ostap E.M.
J. Muscle Res. Cell Motil.28:285-291(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYO1C
10.

"Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members."
Denofrio J.C. , Yuan W. , Temple B.R. , Gentry H.R. , Parise L.V.
Thromb. Haemost.100:847-856(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITGA2B;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
11.

"CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3."
Naik M.U. , Nigam A. , Manrai P. , Millili P. , Czymmek K. , Sullivan M. , Naik U.P.
J. Thromb. Haemost.7:1906-1914(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
12.

"Tumor growth and angiogenesis is impaired in CIB1 knockout mice."
Zayed M.A. , Yuan W. , Chalothorn D. , Faber J.E. , Parise L.V.
J. Angiog. Res.2:17-17(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"CIB1 is a regulator of pathological cardiac hypertrophy."
Heineke J. , Auger-Messier M. , Correll R.N. , Xu J. , Benard M.J. , Yuan W. , Drexler H. , Parise L.V. , Molkentin J.D.
Nat. Med.16:872-879(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CACNA1C AND PPP3R1;SUBCELLULAR LOCATION;INDUCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
14.

"Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration."
Kostyak J.C. , Naik M.U. , Naik U.P.
Blood119:838-846(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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